![]() 4 Nifedipine (2 x 1O-6 M) inhibited the responses to pilocarpine and nicotine. The enhanced response was blocked by atropine (10-6 M) but not by hexamethonium (5 x 10-4M). The effect of ouabain was much more significant on noradrenaline secretion than on adrenaline secretion. The ratio of adrenaline to noradrenaline was not affected by ouabain.3 In the absence of extracellular Ca2 +, ACh and pilocarpine, but not nicotine, still caused a small increase in catecholamine secretions, which were enhanced by treatment with ouabain (10-M) plus Ca2 + (2.2 mM) for 25 min. ![]() Both ACh and nicotine released more noradrenaline than adrenaline and the reverse was the case for pilocarpine.2 Ouabain (10-M) enhanced catecholamine secretion induced by ACh (10`M), pilocarpine (10-3M) and nicotine (3 x 10-6 M) during perfusion with Locke solution. Acetylcholine (ACh) (5 x 1O-7 to 10-M), pilocarpine (10-s to 10-3M) and nicotine (10-6 to 5 x 10-IM) caused dosedependent increases in catecholamine secretion. ![]() 1 The effect of ouabain on catecholamine (adrenaline and noradrenaline) secretion induced by agents acting on cholinocepters was studied in perfused cat adrenal glands.
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